Like the coupe, the Lamborghini Gallardo LP560-4 Spyder loses 44 pounds (20 kg) and wins in its 200 cc V-10 engine, making it a new aluminum 5.2 liter with 552 horsepower and 398 pounds / foot in the pedal. Upgraded engine is mated to the six-speed semiautomatic transmission e.gear rescheduled for Lambo Lamborghini ensures that changes to 40% faster in the "Corsican" sportier. The improvements led to a 4.0 s time to go from 0 to 62 mph (0 to 99.8 km / h) and a maximum speed of 201 mph (323.5 km / h) for the LP560-4 Spyder according to the manufacturer. The Gallardo Spyder was outgoing 10/15 mpg (4.3/6.4 km / l) with the conventional transmission lever and 10/16 mpg (4.3/6.8 km / l) with the semi e.gear, but the LP560-4 is 12 / 20 (5.1/8.5 km / l) and 13/20 (5.6/8.5 km / l) respectively. Impressive numbers for a super car.

Also the brakes LP560-4 Spyder was improved. The brake system is standard vented discs 14.4 inches (37 cm) with eight-piston Brembo clamps front and vented discs of 14.0 inches (36 cm) with four piston back jaws.